The Philips Sonicare SimplyClean rechargeable electric toothbrush replacement head is designed to work with multiple Philips Sonicare snap-on handles. SimplyClean brush heads gently removes plaque at the gum line to improve oral health. Reminder bristles fade from blue to white to let you know when it's time to replace your brush head. Replace your brush head every three months as recommended by the American Dental Association. A fresh brush head every three months maximizes the effectiveness of Philips' unique Sonic Technology. The SimplyClean Replacement Electric Toothbrush Head is compatible with Philips Sonicare snap on rechargeable handles; DiamondClean Smart, DiamondClean, FlexCare Connected, FlexCare+, HealthyWhite, 3 Series, 2 Series, Essence+, ProtectiveClean 6100, ProtectiveClean 5100, and ProtectiveClean 4100.